Analysis of the immunological reactivity conditions of burned children was conducted. The factors witch have influence on the functional activity of blood leucocytes were studied. The decrease of immunological reactivity proportionale to the grave of the trauma was discovered. The secondary immunodeficiency in T-indepent type developed. The protein fraction of the blood serum influenced on the T-lymphocytes to the highest degree. Simultaneously decrease of the toleranse to the autologus erytrocytes with the hyperproduction of antibodies was discovered.