The results of observations on children with acute virus respiratory infections (ARVI) and who had long been residents of zones with different levels of technogenic pollution of the atmospheric air are presented. The technogenic pollution of the environment has been found to exert influence on the spread and clinical course of ARVI in children, this influence being the more pronounced, the higher is the level of xenobiotics in the atmospheric air. The severity of the disease is noted to depend on the development of a number of syndromes, aggravating the course of ARVI, such as the neurotoxic and bronchoobstructive syndromes. Bronchical and ENT lesions are the most frequent complication of the main disease. The child population residing under the conditions of high technogenic environmental pollution should be regarded as a group of risk subject to the aggravated course of ARVI, and the examination of sick children should be made with due regard to this circumstance.