The demand for research in the context of identifying the relationship between socioeconomic factors and the medical and demographic indicators of individual regions is conditioned by continuing deterioration of the health status of population of the subjects of the Russian Federation, which occurs under the influence of unfavorable environmental factors. The purpose of research is to carry out comprehensive analysis of the medical and demographic indicators of population health of the region in 2012-2017, taking into account the influence of regional health factors. Materials and methods. The study applied such research techniques as the Pearson's correlation analysis with matrix construction. The processing was performed using the software Statistica 6.0. To test the hypothesis of normal distribution, the Shapiro-Wilk criterion was applied. The significance of differences was determined by the Student's criterion. The differences were considered statistically significant with p