The article substantiates the relevance of the study of the essence, tools and mechanisms of digital transformation of the health sector. A comparative assessment of the current health care system in the cities of the world is presented, trends in the use of end-to-end technologies for improving the health care system in Russia are revealed. The development of the health sector in modern conditions is based on the introduction of new information and communication technologies, for the proactive use of which, it is necessary to increase the digital skills and awareness of health workers and the population. The national projects of the Russian Federation «Health care» and «Digital economy» speak about the need to implement design solutions for the formation of competence models of personnel in the conditions of global digitalization. The formation of the digital contour of the health sector should be based on a clear understanding of the competence profile, its inclusion in the innovative health care system and the preservation of human capital. The use of competence approach to the digital transformation of healthcare contributes to improving the adaptability of the existing system of health organization to the new technological order provides the possibility of introducing cross-cutting technologies in the processes of decision-making to improve the accessibility and quality of care.