DNA damage in Arctic seabirds: Baseline, sensitivity to a genotoxic stressor, and association with organohalogen contaminants.

https://arctichealth.org/en/permalink/ahliterature296924

Source: Environ Toxicol Chem. 2018 04; 37(4):1084-1091

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Date: 04-2018

Author: Ane Haarr; Ketil Hylland; Norith Eckbo; Geir Wing Gabrielsen; Dorte Herzke; Jan Ove Bustnes; Pierre Blévin; Olivier Chastel; Børge Moe; Sveinn Are Hanssen; Kjetil Sagerup; Katrine Borgå

Author Affiliation: Department of Biosciences, University of Oslo, Oslo, Norway.

Source: Environ Toxicol Chem. 2018 04; 37(4):1084-1091

Date: 04-2018

Language: English

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Keywords: Animals; Arctic Regions; Charadriiformes - metabolism; DNA Breaks, Double-Stranded - drug effects; DNA Damage; Environmental monitoring; Environmental Pollutants - toxicity; Hydrocarbons, Halogenated - toxicity; Lipids - analysis; Mutagens - toxicity; Principal Component Analysis

Abstract: Environmental contaminants are found throughout Arctic marine ecosystems, and their presence in seabirds has been associated with toxicological responses. However, there are few studies of genotoxicity in Arctic avian wildlife. The purpose of the present study was to quantify deoxyribonucleic acid (DNA) damage in lymphocytes of selected seabird species and to examine whether accumulation of organohalogen contaminants (SOHCs) affects DNA damage. Blood was sampled from common eider (Somateria mollissima), black guillemot (Cepphus grylle), black-legged kittiwake (Rissa tridactyla), glaucous gull (Larus hyperboreus), arctic skua (Stercorarius parasiticus), and great skua (Stercorarius skua) in Kongsfjorden, Svalbard (Norway). Contaminant concentrations found in the 6 species differed, presumably because of foraging ecology and biomagnification. Despite large differences in contaminant concentrations, ranging from SOHCs 3.3?ng/g wet weight in the common eider to SOHCs 895?ng/g wet weight in the great skua, there was no strong difference among the species in baseline DNA damage or sensitivity to a genotoxic stressor (hydrogen peroxide). Baseline levels of DNA damage were low, with median values ranging from 1.7% in the common eider to 8.6% in the great skua. There were no associations between DNA damage and contaminants in the investigated species, suggesting that contaminant concentrations in Kongsfjorden are too low to evoke genotoxic effects, or possibly that lymphocytes are resistant to strand breakage. Clearly, genotoxicity is a topic for future studies of Arctic seabirds. Environ Toxicol Chem 2018;37:1084-1091. © 2017 SETAC.

PubMed ID: 29120089 View in PubMed