Indigenous Peoples in Canada continue to experience health and social inequities in the post-colonial era. The Inuit are one aggregate whose livelihoods have been drastically altered through government subsistence programs and residential schools. The loss of culture, community, and relationships have had a negative impact on this population, particularly youth, as evidenced by high rates of suicide and issues with mental health and substance abuse. A search of scholarly and gray literature was completed to identify factors that contribute to suicide among Inuit youth and potential interventions. While interventions that address mental health and suicidal risk factors have been successful, resources to support programs have not been sustained. This paper highlights suicide and mental illness among Inuit youth as a preventable issue that stakeholders and policymakers can address through participatory approaches in collaboration with the community.