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Cannabis Use and Incidence of Testicular Cancer: A 42-Year Follow-up of Swedish Men between 1970 and 2011.
https://arctichealth.org/en/permalink/ahliterature292471
Source
Cancer Epidemiol Biomarkers Prev. 2017 Nov; 26(11):1644-1652
Publication Type
Journal Article
Date
Nov-2017
More detail
Author
Russell C Callaghan
Peter Allebeck
Olof Akre
Katherine A McGlynn
Anna Sidorchuk
Author Affiliation
Northern Medical Program, University of Northern British Columbia, Prince George, British Columbia, Canada. russ.callaghan@unbc.ca.
Source
Cancer Epidemiol Biomarkers Prev. 2017 Nov; 26(11):1644-1652
Date
Nov-2017
Language
English
Publication Type
Journal Article
Keywords
Aged
Cannabis - adverse effects
Follow-Up Studies
Humans
Incidence
Male
Marijuana Smoking - adverse effects - epidemiology - legislation & jurisprudence
Proportional Hazards Models
Registries - statistics & numerical data
Risk factors
Surveys and Questionnaires
Sweden - epidemiology
Testicular Neoplasms - epidemiology - etiology
Abstract
Background: Given current drug policy reforms to decriminalize or legalize cannabis in numerous countries worldwide, the current study assesses the relation between cannabis use and the development of testicular cancer.Methods: The study included a population-based sample (n = 49,343) of young men ages 18-21 years who underwent conscription assessment for Swedish military service in 1969-1970. The conscription process included a nonanonymous questionnaire eliciting information about drug use. Conscription information was linked to Swedish health and administrative registry data. Testicular cancers diagnosed between 1970 and 2011 were identified by International Classification of Diseases-7/8/9/10 testicular cancer codes in the Swedish National Patient Register, the Cancer Register, or the Cause of Death Register. Cox regression modeling was used to estimate the hazards associated with cannabis use and time to diagnosis of testicular cancer.Results: No evidence was found of a significant relation between lifetime "ever" cannabis use and the subsequent development of testicular cancer [n = 45,250; 119 testicular cancer cases; adjusted HR (aHR), 1.42; 95% confidence interval (CI), 0.83-2.45]. "Heavy" cannabis use (defined as usage of more than 50 times in lifetime, as measured at conscription) was associated with the incidence of testicular cancer (n = 45,250; 119 testicular cancer cases; aHR 2.57; 95% CI, 1.02-6.50).Conclusions: The current study provides additional evidence to the limited prior literature suggesting cannabis use may contribute to the development of testicular cancer.Impact: Emerging changes to cannabis drug policy should consider the potential role of cannabis use in the development of testicular cancer. Cancer Epidemiol Biomarkers Prev; 26(11); 1644-52. ©2017 AACR.
Notes
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PubMed ID
29093004
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