Iodine deficiency during pregnancy may influence maternal and foetal thyroid function with the risk of causing neurocognitive and psychomotor deficits in the offspring. The objective of this study was to assess iodine status in pregnant women from Northern Norway and to investigate the influence of iodine status on maternal and infant thyroid function.
Women from the Northern Norway Mother-and-Child contaminant Cohort Study (MISA) donated a blood and urine sample at three visits during their pregnancy and postpartum period (in second trimester, 3 days and 6 weeks after delivery. N=197). Women were assigned to iodine status groups according to urine iodine concentrations (UICs) in second trimester and mixed effects linear models were used to investigate potential associations between iodine status and repeated measurements of thyroid-stimulating hormone (TSH), thyroid hormones (THs), TH-binding proteins and thyroid peroxidase antibodies. Associations between maternal iodine status and TSH in heel prick samples from the infants were investigated with linear regression.
Median UIC in second trimester was 84?µg/l (range 18-522) and 80% had UIC below recommended level (
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Cites: J Trace Elem Med Biol. 2013 Oct;27(4):302-6 PMID 23992867
Cites: BMC Endocr Disord. 2008 Nov 27;8:15 PMID 19036169
Cites: J Environ Monit. 2010 Nov;12(11):2128-37 PMID 20877852
