The MDM2 promoter region contains several polymorphisms, some of which have been associated with MDM2 expression, cancer risk and age at cancer onset. del1518 (rs3730485) is an indel polymorphism residing in the MDM2 promoter P1 and is in almost complete linkage disequilibrium with the MDM2 promoter P2 polymorphism SNP309T>G (rs2279744). Cancer risk assessments of del1518 have previously been conducted in relatively small Chinese populations only. In this study we assessed the genotype distribution of del1518 among healthy Caucasians, African Americans and Chinese, and we estimated the Odds Ratios (OR) for incident cancer of the breast, colon, lung and prostate (n=7,081) as compared to controls (n=3,749) in a large Caucasian (Norwegian) cohort.We found the genotypes of the del1518 to vary significantly between healthy Caucasians, African-Americans and Chinese (p
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Cites: Cancer Lett. 2006 Aug 28;240(2):261-716288830
Cites: Nature. 1992 Jul 2;358(6381):80-31614537
Cites: Int J Cancer. 2002 Oct 10;101(5):403-812216066
Cites: Int J Epidemiol. 2008 Jun;37(3):481-517984119
Cites: Nucleic Acids Res. 2004 Jan 1;32(Database issue):D91-414681366
Cites: Nucleic Acids Res. 1998 Aug 1;26(15):3453-99671804
Cites: Cancer Res. 2006 May 15;66(10 ):5104-1016707433
Cites: BMC Cancer. 2008 Oct 01;8:28118828900
Cites: Am J Hum Genet. 2008 Aug;83(2):243-5318674748
Cites: Cancer Prev Res (Phila). 2014 Dec;7(12 ):1210-825281486
Cites: Int J Biol Markers. 2012 Jul 19;27(2):e105-1022467100
Cites: Int J Cancer. 2006 Mar 1;118(5):1275-816152608