Following animal model data indicating the possible rejuvenating effects of blood from young donors, there have been at least 2 observational studies conducted with humans that have investigated whether donor age affects patient outcomes. Results, however, have been conflicting.
To study the association of donor age and sex with survival of patients receiving transfusions.
A retrospective cohort study based on the Scandinavian Donations and Transfusions database, with nationwide data, was conducted for all patients from Sweden and Denmark who received at least 1 red blood cell transfusion of autologous blood or blood from unknown donors between January 1, 2003, and December 31, 2012. Patients were followed up from the first transfusion until death, emigration, or end of follow-up. Data analysis was performed from September 15 to November 15, 2016.
The number of transfusions from blood donors of different age and sex. Exposure was treated time dependently throughout follow-up.
Hazard ratios (HRs) for death and adjusted cumulative mortality differences, both estimated using Cox proportional hazards regression.
Results of a crude analysis including 968?264 transfusion recipients (550?257 women and 418?007 men; median age at first transfusion, 73.0 years [interquartile range, 59.8-82.4 years]) showed a U-shaped association between age of the blood donor and recipient mortality, with a nadir in recipients for the most common donor age group (40-49 years) and significant and increasing HRs among recipients of blood from donors of successively more extreme age groups (
Notes
Cites: Cell. 2013 May 9;153(4):828-3923663781
Cites: JAMA. 2012 Oct 10;308(14):1443-5123045213
Cites: Science. 2014 May 9;344(6184):630-424797482
Cites: N Engl J Med. 2015 Apr 9;372(15):1419-2925853746
Cites: Science. 2014 May 9;344(6184):649-5224797481
Cites: Transfusion. 2015 Jul;55(7):1600-625573303
Cites: Epidemiol Perspect Innov. 2008 Nov 14;5:719014582
Cites: Circulation. 2016 Nov 22;134(21):1692-169427881511