In a recent expert meeting, Swedish recommendations for the treatment of HCV infection were updated. An interferon-free combination of direct-acting antiviral agents was recommended as the first line standard-of-care treatment for chronic HCV infection. Interferon-based therapy should be considered as a second line option after an individual benefit-risk assessment. Treatment is strongly recommended for HCV infected patients with bridging fibrosis or cirrhosis (Metavir stages F3-4), before and after liver transplantation, and in the presence of extra-hepatic manifestations. Additionally, patients with moderate liver fibrosis (stage F2) as well as women in need of in vitro fertilisation should be prioritised for therapeutic intervention. Treatment indications for people who inject drugs, children, chronic kidney disease and HIV co-infection are also discussed.
Cites: N Engl J Med. 2014 Apr 17;370(16):1483-9324725238
Cites: Lancet. 2014 Nov 15;384(9956):1756-6525078309
Cites: N Engl J Med. 2014 Apr 24;370(17):1604-1424720679
Cites: N Engl J Med. 2014 May 22;370(21):1983-9224795200