In vitro production of immunoregulatory cytokines (IFN-a, IL-31, TNF-Ã?, IL-17A, IL-7, IL-1RA, IL-1a, IL-10, IL-15, IL-21, IL-22, IL-23, IL-27, and IL-9) by dendritic cell cultures was compared in ski athletes and healthy donors. Effect of prolonged intense physical exercise on secretory activity of immune cells was investigated. In both groups, secretion of IL-1RA, IL-10, IL-1a by dendritic cells was revealed, but there were significant differences in IL-1RA, IL-1a content (p