High physical activity has been shown to decrease the risk of breast cancer, potentially by a mechanism that also reduces mammographic density. We tested the hypothesis that the risk of developing breast cancer in the next 10 years according to the Tyrer-Cuzick prediction model influences the association between physical activity and mammographic density.
We conducted a population-based cross-sectional study of 38,913 Swedish women aged 40-74 years. Physical activity was assessed using the validated web-questionnaire Active-Q and mammographic density was measured by the fully automated volumetric Volpara method. The 10-year risk of breast cancer was estimated using the Tyrer-Cuzick (TC) prediction model. Linear regression analyses were performed to assess the association between physical activity and volumetric mammographic density and the potential interaction with the TC breast cancer risk.
Overall, high physical activity was associated with lower absolute dense volume. As compared to women with the lowest total activity level (
Notes
Cites: Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1473-8221610220
Cites: Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1764-7225012995
Cites: N Engl J Med. 2001 Jan 25;344(4):276-8511172156
Cites: J Endocrinol. 2001 Jul;170(1):3-1111431132
Cites: Am J Epidemiol. 2002 Sep 1;156(5):402-912196309
Cites: JAMA. 2003 Sep 10;290(10):1331-612966124
Cites: Stat Med. 2004 Apr 15;23(7):1111-3015057881
Cites: Cancer Res. 2004 Apr 15;64(8):2923-815087413
Cites: Nature. 1983 Jun 30;303(5920):767-706866078
Cites: Br J Cancer. 1987 Jun;55(6):681-53620313
Cites: Am J Epidemiol. 1989 Jun;129(6):1120-312729251
Cites: Epidemiol Rev. 1993;15(1):36-478405211
Cites: J Natl Cancer Inst. 1994 Sep 21;86(18):1403-88072034
Cites: J Natl Cancer Inst. 1995 May 3;87(9):670-57752271
Cites: N Engl J Med. 1997 May 1;336(18):1269-759113929
Cites: Int J Obes Relat Metab Disord. 1997 Oct;21(10):941-79347414
Cites: Breast Cancer Res. 2004;6(6):229-3915535852
Cites: Phys Med Biol. 1994 Oct;39(10):1629-3815551535
Cites: J Natl Cancer Inst. 2005 Apr 20;97(8):595-60215840882
Cites: Am J Epidemiol. 2005 Nov 1;162(9):826-3416177147
Cites: Med Sci Sports Exerc. 2006 Feb;38(2):240-516531890
Cites: Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):456-6016537701
Cites: Breast Cancer Res Treat. 2006 Jan;95(2):171-816319988
Cites: Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1159-6916775176
Cites: Int J Cancer. 2006 Oct 1;119(7):1695-70116688715
Cites: J Natl Cancer Inst. 2006 Oct 4;98(19):1406-1517018787