Immediate and long-term results of surgical treatment of infective valvular endocarditis (IVE) in 438 patients during the period from 1978 to 2013 are presented. Overall hospital mortality was 9.1% (11.2 and 6.7% among patients operated in the active stage of IVE and in remission, respectively) Depending on the site of infection mortality was: aortic valve (AV) - 7.9, mitral valve (MV) 10.1, MV and AV 10.7, tricuspid valve (TV) 6 7%. Overall 5 and 10 year survival after surgery was 78.6 4.7 and 66.2 3.9%, respectively. The lowest 5 and 10 year survival was observed in patients with MV and AV defects (66.3 and 52.7%, respectively). Long-term follow-up, the most consistent results are indicated in patients undergoing surgery with primary IE: to 1 year after surgery 94.5% survived to 5 year - 87%, to 10 - 85.5% of patients. In the group of patients with secondary IE to the first, fifth and tenth year observation survived 86.3%, 77.4%, 70.6%, respectively. The main reason for poor results was increasing heart failure, and recurrent infection.