Children participating in longitudinal type 1 diabetes prediction studies were reported to have less severe disease at diabetes diagnosis. Our aim was to investigate children who from birth participated in the Diabetes Prediction in Skåne (DiPiS) study for metabolic status at diagnosis and then continued to be followed for 2 yr of regular clinical care.
Children, followed in DiPiS before diagnosis, were compared to children in the same birth cohort, who did not participate in follow-up. Metabolic status, symptoms at diagnosis as well as hemoglobin A1c (HbA1c) and doses of insulin at 3, 6, 12, and 24 months after diagnosis were compared.
Children, followed in DiPiS and diagnosed at 2-12 yr of age, had 0.8% (9?mmol/mol) lower HbA1c at diagnosis than those who were not followed (p?=?0.006). At diagnosis, fewer DiPiS children had symptoms (p?=?0.014) and ketoacidosis at diagnosis were reduced (2% compared to 18%, p?=?0.005). During regular clinical care, HbA1c levels for the DiPiS children remained lower both at 12 (0.4% (4?mmol/mol); p?=?0.009) and 24 months (0.8% (9?mmol/mol) p ?