While studying the course of the disease in 2143 patients with macrofocal myocardial infarction it was found that with significant departure from mean for the city of Leningrad values of relative air humidity, intensity of terrestrial magnetism and differentials of atmospheric pressure the incidence of major complications of the disease is on the increase. An analysis of pertinent data leads to the conclusion on the need of arranging trial-tests to verify the effect on the course of acute myocardial infarction of the patient's stay in a specially equipped ward, where the parameters of the physical environmental factors are maintained at levels mean for a given locality.