The data on resistance to 10 antibiotics and sulfanilamides of 178 coprocultures of Enterobacteriaceae isolated from patients in the Ulyanovsk Region are presented. It is indicated that 93.8 per cent of the isolates were resistant to the antibiotics. The majority of the cultures were resistant to ampicillin, tetracycline and streptomycin and sensitive to gentamicin, polymyxin, trimetoprim, rifampicin and nalidixic acid. 43 combinations of the antibiotic resistance types were revealed. 92.7 per cent of the isolates were resistant to the sulfanilamides.