In this study we examined the case histories of 163 living and 82 deceased adult Finnish patients with acute hepatic porphyria. There were 184 patients with acute intermittent porphyria and 61 patients with variegate porphyria. Among the 124 of the 163 living patients, who were traced 1984-1985, no hepatocellular carcinoma was found. Among the 82 deceased patients the cause of death was porphyria in 29 (36%), cardiovascular disease in 23 (29%) and hepatocellular carcinoma in 7 (9%). Of the 7 patients with hepatocellular carcinoma, 6 had acute intermittent porphyria and one had variegate porphyria. In acute hepatic porphyria, as compared with the total population, the calculated risk of hepatocellular carcinoma is increased 61-fold.
Notes
Cites: Neoplasma. 1972;19(2):135-94336890
Cites: Rev Czech Med. 1962;8:290-513970921
Cites: Acta Med Scand. 1976;200(3):171-8970225
Cites: Ann Clin Res. 1976;8 Suppl 17:133-81008483
Cites: Lancet. 1978 Dec 9;2(8102):1217-982732
Cites: Biochem Biophys Res Commun. 1980 Jul 16;95(1):170-67417246