Myoelectric controls research began at the University of New Brunswick in 1960, and has continued without interruption since that time. The Bio-Engineering Institute has emphasized control systems which meet special clinical needs. These have included systems for amputees with only a single muscle remnant with which to control a prosthesis and, more recently, systems which provide the best possible appearance for children and for infants as young as 15 months of age. Throughout this work, however, the Institute has maintained a fundamental interest in the problem of control of complex multifunction prostheses. With recent developments in electromechanical systems this more advanced controls research will find clinical application shortly.