The survey was conducted in Saint-Petersburg in 1987-1992. New approaches to preventing tuberculosis were defined under the conditions of the large city, taking into account the trends revealed in the epidemiology and clinical and epidemiological findings of 4165 children (431 from the active tuberculosis foci, 168 who had contacts with persons of Dispensary registration Group VII, 3566 from the healthy environment) and 11,434 adults (9941 healthy subjects, 1059 from a risk group, and 434 bacterial isolates). It was shown that there was a need to broaden the list of pediatric and adult populations to be more thoroughly studied in order to detect tuberculosis (to identify new risk groups), that there is advisability to apply a differential approach to BCG revaccination of adults in relation to the epidemiological situation, to make activities better in the foci of tuberculosis infection, by expanding their limits. It is quite necessary to make comprehensive antituberculosis measures with regards for the socioeconomic, demographic, and ecological features of the city.