Anticipation describes an inheritance pattern within a pedigree with an increase in disease severity or decrease in age at onset or both in successive generations. The phenomenon of anticipation has recently been shown to be correlated with the expansion of trinucleotide repeat sequences in different disorders. We have studied differences of age at onset and disease severity between two generations in 14 families with unilinear inheritance of bipolar affective disorder (BPAD). There was a significant difference in age at onset (p
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Cites: Br J Psychiatry. 1977 Apr;130:330-51558030
Cites: Nat Genet. 1993 Aug;4(4):398-4038401589
Cites: Am J Psychiatry. 1982 Feb;139(2):209-127055292
Cites: Nature. 1987 Feb 26-Mar 4;325(6107):783-72881209
Cites: Nature. 1987 Mar 19-25;326(6110):289-923493438
Cites: Arch Gen Psychiatry. 1987 May;44(5):441-73579495
Cites: J Med Genet. 1988 Sep;25(9):589-952972838
Cites: Brain. 1989 Jun;112 ( Pt 3):779-972731029
Cites: Nature. 1989 Nov 16;342(6247):238-432682265