To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample.
Cross sectional population based study.
980 people aged 69 to 78 (349 men, 631 women).
Population of Kuopio, eastern Finland.
Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation.
46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 subjects without dementia (P
Notes
Cites: BMJ. 1991 Nov 9;303(6811):1159-621747611
Cites: Am J Hum Genet. 1991 Mar;48(3):563-831998342
Cites: Genet Epidemiol. 1992;9(3):155-671381696
Cites: Lancet. 1992 Oct 10;340(8824):879-801357300
Cites: Science. 1992 Oct 23;258(5082):668-711411576
Cites: Lancet. 1992 Nov 28;340(8831):13501360057
Cites: Science. 1993 Aug 13;261(5123):921-38346443
Cites: Neurology. 1993 Aug;43(8):1467-728350998
Cites: Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8098-1028367470