Psychosomatic borderline disorders were observed in 366 individuals during prophylactic medical examination of 675 employers of big oil-chemical enterprise. The main group consisted of 189 cases of psychosomatic disturbances. They included the very borderline disorders (neuroses, psychogenic depressions, psychopathies) as well as cyclothymias and schizothymic personal deviations too. The majority of disorders were presented by depressive and asthenic syndromes cases. The direct correlation was found between the frequencies of such disturbances rise and the duration of industrial work in conditions of professional hazards. The role of social and cultural factors in psychosomatic disorders development was also established.