The course of Flexner dysentery has been analysed in 110 fatal cases. They died in St. Petersburg in 1994. Fatal outcomes occurred more frequently in the elderly and unsuccessful subjects. Hospitalization in many cases was late. Dysentery ran often in the presence of concomitant disorders (cardiovascular, alcoholic, alimentary) and was complicated with shock, pneumonia, peritonitis. At autopsy, there were severe catarrhal, fibrinolytic, flegmonous, hemorrhagic, ulcerative and necrotic lesions of both large and small intestine.