The coverage of children having different pathology with prophylactic immunization is rather high and reaches, on the average, 82.3 +/- 0.7%. The immunization of children belonging to risk groups according to individual schedules and in combination with different measures aimed at the prevention of postvaccinal complications may be successfully carried out in pediatric practice under the conditions of a common polyclinic. After the vaccinal prophylaxis of such groups of children no postvaccinal complications and reactions to the administered immunobiological preparations have been observed.