The data of clinical current of sepsis in 239 wounded with syndrome of system inflammatory reaction (SIR) are investigated. Frequency of sepsis in complications of gun-shot wounds has made 5.4%. At the same time syndrome SIR is diagnosed in 23.4% of cases, that was the indication to realization of the whole complex of antiseptic treatment. Therapy of sepsis included some components: drainage and removal of the septic center; the system antibacterial therapy; the controlled hypocoagulation; immunotherapy; active detoxication; power and trophic support on the basis of balanced feed. The used principles of early diagnostics and multicomponent therapy of surgery of sepsis have allowed to lower lethality up to 29.3% and in sepsis of wound--up to 9.1%.