To analyse the association between the G/A polymorphism in the apolipoprotein A-1 (apo A-1) promoter region and plasma lipid levels, as well as their responses to dietary change, in Finnish adults.
Blood samples from 86 subjects (42 men. 44 women) who attended a dietary intervention study carried out in North Karelia in 1993 were available for the current analysis. The diet study consisted of a 2-week baseline period, followed by an 8-week intervention period, and an 8-week switchback period.
Diet was modified to a low-fat, low-cholesterol diet during the dietary intervention.
Fasting plasma lipid, lipoprotein and apoliprotein levels were determined.
At baseline, the high-density lipoprotein (HDL) cholesterol and apo A-1 levels were higher (P