Tuberculous infection is no longer controllable in Moscow. Tuberculosis ranks first in the structure of morbidity caused by monoinfections. The prevalence of tuberculosis is increasing both among adults and children. Increasing incidence of forms with bacterial release is especially dangerous. Such patients represent the greatest epidemic hazard for the population. In Moscow the situation with tuberculosis is characterized by a notable reservoir of infection among socially maladapted subjects. A special department for this patient population was created in tuberculosis hospital No. 11; besides medical care, the patients are rendered social care there. The situation with tuberculosis in Russia and in Moscow requires urgent measures aimed at stabilization of the epidemiological process.