The analysis using the systems approach, analogue simulation, practical conclusions of the probability theory, mathematical statistical methods, programme-oriented work organization revealed and eliminated a number of neglects that had put bounds to scabies morbidity reduction among Moscovites. In 1998, the number of the foci that dermatovenereological facilities were unaware of substantially showed a 6.9-fold decrease. Therefore, the incidence of scabies reduced by 14.6% in the city in 1998. The paper presents the guidelines developed by the authors, which will ensure that the incidence rates of scabies be 25.07 per 100,000 Moscovites by 2005. It analyzes the scabies epidemiological situation among the homeless and possible measures to promote health in this group of persons.