Methodological, technological, and organization characteristics of efficiency evaluation of specialists and hygienic departments engaged in a State Sanitary Surveillance (SSS) Center of the first level of management are presented. Main notions concerning the efficiency of SSS are formulated. A method for quantitative evaluation of the quality is offered, allowing comparison of compatible and equivalent parameters. Validation for mathematical models of efficiency and quality criteria is offered. Computer technology Sanepidotsenka (Sanitary epidemiological evaluation) is offered, which is used in the regulation of SSS Center activities aimed at maintenance of sanitary and epidemiological well-being of territories.