The paper presents the results of qualitative and quantitative analyses of air allergenic chemical pollution of the environment of development lands of Orenburg. The pollutants forming an allergic load are identified. Additive exposure to chromium and vanadium was found to be a priority parameter. The main stationary sources of air pollution with chemical allergens in the city were motor-vehicle transport and, to a lesser extent, the open joint-stock company Invertor, the production association Strela, the sleeper-impregnating plant, the gas-processing plant, the joint-stock company Radiator, the furniture factory, and the locomotive-repairing plant. The Industrial District of the city was ascertained to be a highest-risk area. The greatest allergenic load has been recorded in winter months.