Aim of the study was to elucidate relationship between complex effect on organism of unfavorable ecological factors of high altitudes and course of ischemic heart disease (IHD) and hypertensive disease in Surgut (Khanty-Mansi Autonomous District). Five year medico-ecological monitoring established direct relation between dynamics of average monthly hospital admissions of patients with IHD and hypertension, level of atmospheric pressure and concentration of phenol in the air. Complex of nature conservation measures resulted in decreases of frequency of hospitalizations as well as cardiovascular morbidity with temporary loss of working capacity.