The phospholipid transfer protein (PLTP) may play a role in body fat regulation.
To investigate the association between PLTP genetic variants and obesity-related phenotypes.
Two intronic variants, one in intron 1 (c.-87G>A) and the other in intron 12 (c.1175+68T>G), were genotyped in 811 participants of the Québec Family Study. Nine obesity-related phenotypes were investigated, including body mass index (BMI), obesity (BMI> or =30 kg/m(2)), and waist circumference, percentage of fat, fat mass and fat-free mass measured by hydrostatic weighing as well as total, visceral and subcutaneous abdominal adipose tissue areas assessed by computed tomography. Single markers and haplotypes were tested for associations in family-based designs using the FBAT program.
The SNP located in intron 1 showed significant associations with obesity, BMI, waist circumference and fat-free mass (P
