This research examined the associations of unipolar depression with immature dependence and self-criticism (S.J. Blatt et al., 1995) in a sample of graduate students with a diagnosed history of depression. A battery of tests was completed by 158 students, and a subset (n =102) was reached approximately 20 months later for the assessment of new depressive onsets. Self-criticism and neuroticism were uniquely associated with a past history of depression, and self-criticism and immature dependence interacted in predicting past occurrences of depression. Self-criticism was increasingly associated with past depressive episodes as level of immature dependence increased. The interaction of immature dependence and self-criticism was also evident in predicting future occurrence of depression after controlling statistically for the effects of current symptoms, neuroticism, certain Axis II diagnoses, and number of previous depressive episodes. This interactive effect suggests that individuals with high levels of both self-criticism and immature dependence are particularly prone to depressive episodes.