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A timing-of-birth effect on multiple sclerosis clinical phenotype.
https://arctichealth.org/en/permalink/ahliterature162699
Source
Neurology. 2007 Jul 3;69(1):60-2
Publication Type
Article
Date
Jul-3-2007
More detail
Author
A D Sadovnick
P. Duquette
B. Herrera
I M L Yee
G C Ebers
Author Affiliation
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada. sadovnik@infinet.net
Source
Neurology. 2007 Jul 3;69(1):60-2
Date
Jul-3-2007
Language
English
Publication Type
Article
Keywords
Canada - epidemiology
Disease Susceptibility
Female
Humans
Male
Multiple Sclerosis, Chronic Progressive - epidemiology
Multiple Sclerosis, Relapsing-Remitting - epidemiology
Parturition
Phenotype
Pregnancy
Prenatal Exposure Delayed Effects
Seasons
Sex ratio
Siblings
Abstract
A month-of-birth (MOB) effect has been shown in multiple sclerosis (MS).
Our chi(2) analyses looked at whether this MOB effect differed by MS phenotype ("bout onset," "primary progressive").
The MOB effect was derived from "bout onset" MS patients (May/November ratio = 1.43; chi(2) = 17.32, df = 1, p = 0.000032).
An unspecified environmental effect in early development can influence both multiple sclerosis susceptibility and phenotype.
PubMed ID
17606881
View in PubMed
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