This study examined the role of occupations and industries in explaining differences among workers reporting poorer mental health in the Canadian workforce. It used data coming from a large representative sample of 77,377 workers engaged in 139 occupations and 95 industries. Logistic regression analysis was used to identify differences in the odds of reporting poorer mental health, adjusting for gender, age, education, marital status, and household income. Results identify ten occupations and nine industries at higher risk for workers reporting poorer mental health. The article concludes by highlighting implications for actors and policymakers and by specifying potential targets for intervention.