Analysis of the course and rate of progression of morphologically confirmed forms of chronic glonerulonephritis (CGN) with onset in childhood and adolescence (1950 to 2005).
The course of the disease was examined in 110 patients with morphologically verified form of CGN with onset in childhood. Maximal history of CGN was 42 years.
CGN was morphologically mesangio-proliferative in 50.9% patients, while nephritis with minimal alterations occurred only in 10% patients. Most of the patients (71; 64.6%) had secondary hypertension, chronic renal failure (39; 35.5%). Programmed hemodialysis was conducted in 14 (12.7%) patients, 10 (9.1%) patients died. Stable dysability developed in 41 (37.3%) patients. The most severe course of the diseases was observed in patients with family history of CGN.
Recently, CGN with debut in childhood shows a trend to an unfavourable course, had severe manifestations at a disease debut, and progresses rapidly.