Unfavourable environmental factors of industry in the cities can cause changes in male reproductive system leading to infertility. The majority of chemical substances revealed in the atmosphere and in the ground of cities and regions are reprotoxicants with damaging effects on different stages of germinal cells maturation. Besides the environmental factors some occupational pollutants can have gonadotropic activity and also result in the disturbances of spermatogenesis. High incidence of male infertility dictates the necessity of wide-scale nature-conservative measures to protect environment and men from aggressive environmental factors.