A questionnaire survey made in different Voronezh population groups suggests that they spend 80 to 90% of time in the enclosed space. The greatest contribution to the chemical load caused by ambient air pollution made by production areas (54.9%) in the adult able-bodied population and by dwelling areas (56.0-86.9%) in children, adolescents, and pensioners. Pollution of ambient air (K = 9.19) is pronounced to a lesser degree than that of the air of office buildings (K = 12.49), which suggests that there are internal contamination sources in the closed space. The results of the questionnaire survey of respondents suggest that 20% suffer from allergic diseases and 7% of them associate these diseases with dwelling area contamination.