Can family physicians help patients initiate basal insulin therapy successfully?: randomized trial of patient-titrated insulin glargine compared with standard oral therapy: lessons for family practice from the Canadian INSIGHT trial.
Department of Family Medicine, Schulich School of Medicine & Dentistry, Centre for Studies in Family Medicine, University of Western Ontario, 245-100 Collip Circle, London, ON N6G 4X8. sharris1@uwo.ca
To determine whether FPs could help patients implement bedtime basal insulin therapy as successfully as diabetes experts could.
National, multicentre, randomized, open-label trial designed to assess use of bedtime basal insulin therapy compared with use of standard oral-agent therapy for patients with type 2 diabetes being treated by diabetes experts or FPs.
Nineteen endocrinologist or expert sites and 34 family practices.
A total of 405 adult patients with hemoglobin A1c (HbA1c) values of 7.5% to 11.0% who were taking 0 to 2 oral agents.
Participants were randomized to receive either basal insulin therapy using glargine self-titrated according to a patient algorithm or conventional therapy with physician-adjusted doses of oral agents for a period of 24 weeks.
The primary outcome was time to achieve 2 consecutive HbA1c values
Notes
Cites: J Fam Pract. 2004 Mar;53(3):215-2215000929
Cites: Diabetes Res Clin Pract. 2007 Nov;78(2):254-817490781