The results of the study of 158 patients with alcohol dependence, comorbid in 85 cases with slow progressive schizophrenia and in 75 cases with affective disorders (cyclothymia), are viewed in the aspect of a theory of comorbidity. The psychopathological peculiarities of each nosologic form are singled out. The author stresses that establishing of the comorbid pathology is important for the right therapeutic strategy. The effectiveness of using the combinations of neuroleptics, either typical or atypical, and antidepressants (tricyclic, SSRIs etc) is revealed.