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Absence of relationship between tuberculin reactivity and asthmatic symptoms, level of FEV1 and bronchial hyperresponsiveness in BCG vaccinated young adults.
https://arctichealth.org/en/permalink/ahliterature15399
Source
Allergy. 2002 Apr;57(4):336-40
Publication Type
Article
Date
Apr-2002
More detail
Author
H F Jentoft
E. Omenaas
G E Eide
A. Gulsvik
Author Affiliation
Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway.
Source
Allergy. 2002 Apr;57(4):336-40
Date
Apr-2002
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Asthma - drug therapy - physiopathology
BCG Vaccine - therapeutic use
Bronchial Hyperreactivity - drug therapy - physiopathology
Comparative Study
Cross-Sectional Studies
Female
Forced Expiratory Volume - physiology
Humans
Logistic Models
Male
Norway - epidemiology
Predictive value of tests
Prevalence
Questionnaires
Random Allocation
Research Support, Non-U.S. Gov't
Sex Factors
Smoking
Treatment Outcome
Tuberculin - drug effects - physiology
Abstract
BACKGROUND: Some recent studies have suggested that bacillus Calmette-Guérin (BCG) vaccination or mycobacterial infection early in life is inversely related to asthma. We wondered if an increase in tuberculin reactivity was inversely related to commonly used indices of asthma in a population of young adults who were BCG vaccinated at age 14. METHODS: Men and women aged 20-44 years, randomly selected from the general population, were tuberculin tested with the epinephrine-Pirquet method with Norwegian-produced synthetic medium tuberculin (n = 588). In addition they were interviewed using eight questions on asthma symptoms and medication. Lung function and bronchial responsiveness were also tested. RESULTS: Altogether 95% of those studied had been BCG vaccinated at age 14 (n = 558). In the 386 subjects with complete examinations, there was no relationship between a positive tuberculin reaction (> or = 4 mm) and asthma symptoms or use of asthma medication. Furthermore we did not observe any relationship between a positive tuberculin reaction and the level of forced expiratory volume (FEV1) or a positive bronchial responsiveness test, assessed as the percent of predicted of FEV1 and PD20
PubMed ID
11906365
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