A long-term (15 years) investigation of risk factors of locally-advanced recurrences of breast cancer following organ-saving surgery was carried out involving a large number of cases (667). It was shown that tumor size larger than 2 cm (T2), presence of intraductal component (EIC+), high grade (III), lymph node involvement (pN+), multicentricity and positive wound edge contribute to risk of such recurrences by 10-15%.