Division of Geriatric Medicine and Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA. jane.saczynski@umassmed.edu
To examine the association of glycemic status to magnetic resonance imaging indicators of brain pathological changes.
This was a cross-sectional, population-based study of 4,415 men and women without dementia (mean age 76 years) participating in the Age Gene/Environment Susceptibility-Reykjavik Study. Glycemic status groups included the following: type 2 diabetes (self-report of diabetes, use of diabetes medications, or fasting blood glucose > or =7.0 mmol/l [11.1%]); impaired fasting glucose (IFG) (fasting blood glucose 5.6-6.9 mmol/l [36.2%]); and normoglycemic (52.7%). Outcomes were total brain volume, white and gray matter volume, white matter lesion (WML) volume, and presence of cerebral infarcts.
After adjustment for demographic and cardiovascular risk factors, participants with type 2 diabetes had significantly lower total brain volume (72.2 vs. 71.5%; P
Notes
Cites: N Engl J Med. 2004 Apr 1;350(14):1387-9715070788