Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA. jburns@hsph.harvard.edu
Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited. Breast-feeding and diet are two important contributors to early life exposure. To further understand other significant contributors to childhood exposure, we studied a cohort of children from a city with high environmental dioxin levels.
We investigated predictors of serum concentrations of polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs)/co-planar PCBs (C-PCBs), toxic equivalents (TEQs), and PCBs among 8- to 9-year-old boys in Chapaevsk, Russia.
We used general linear regression models to explore associations of log(10)-transformed serum concentrations of PCDDs/PCDFs/C-PCBs, TEQs, and PCBs at study entry with anthropometric, demographic, geographic, and dietary factors in 482 boys in Chapaevsk, Russia.
The median (25th, 75th percentile) concentration for total 2005 TEQs was 21.1 pg/g lipid (14.4, 33.2). Boys who were older, consumed local foods, were breast-fed longer, and whose mothers were employed at the Khimprom chemical plant (where chlorinated chemicals were produced) or gardened locally had significantly higher serum dioxins and PCBs, whereas boys with higher body mass index or more educated parents had significantly lower serum dioxins and PCBs. Boys who lived 5 km away (adjusted mean = 18.8; 95% CI, 17.2-20.6).
Our findings suggest that there are specific local sources of dioxin and PCB exposure among children in Chapaevsk including maternal gardening, consumption of locally grown food, and residential proximity to the Khimprom plant.
Notes
Cites: J Toxicol Environ Health. 1996 Feb 23;47(3):209-208604146
Cites: Environ Int. 2009 Jan;35(1):9-1318602159
Cites: Arch Toxicol. 1997;71(6):383-4009195020
Cites: Prev Med. 1997 Nov-Dec;26(6):808-169388792
Cites: Environ Health Perspect. 1998 May;106(5):273-79520360
Cites: Vopr Pitan. 1998;(3):8-139752664
Cites: Environ Health Perspect. 1999 Jan;107(1):45-519872716
Cites: J Natl Cancer Inst. 1999 May 5;91(9):779-8610328108