The present study investigated the bone health related factors that were associated with the use of bisphosphonates (BP) among 2,050 postmenopausal Finnish women. Low BMD + low trauma energy fracture was the strongest determinant of BP use, while other secondary causes of osteoporosis were less strongly related with BP use. BP use was associated with reduced femoral neck (FN) and lumbar spine (LS) bone loss rate.
The aim was to identify bone health related factors associated with the use of BP in a community setting.
A population-based sample of 2,050 Finnish postmenopausal women was measured with dual X-ray absorptiometry at the FN and LS in 1989, 1994, 1999 and 2004, and information on osteoporosis risk factors, including low-trauma energy fractures, were collected with postal inquiries. Self-reported use of BP in 2004 was considered as the end point variable.
Among BP users, 12% had T-score?>?-2.0 SD and no fracture during follow-up (FU). In women without any bone medication, 26% had T-score??0.05, OR?=?1.35) in multivariate logistic regression. Other factors related with BP use were vitamin D use (p?=?0.001, OR?=?2.27), high number of medications (p?