This study included 80 patients having oncological problems in whom defects resulting from the removal of affected tissues were closed using one-step or delayed reconstruction with a m. pectoralis major flap having axial blood supply The patients of different groups were matched for the main clinical and morphological characteristics. Analysis of the results of reconstructive surgery included evaluation of the influence of specialized treatment in the preceding period (distant gamma-irradiation, chemoradiotherapy and polychemotherapy) on the oncological outcome and post-operative wound healing process after simultaneous and delayed reconstruction. Comparison of five-year survival rates in different groups revealed a tendency toward deterioration of oncological characteristics in patients undergoing one-step plastic correction. Healing success of post-operative wounds at the stage of closure of the defect was unrelated to the type of preceding specialized treatment and the mode of plastic reconstruction (simultaneous or sequential with respect to the main surgical procedure, i.e. removal of the tumour).