The post-mortem inventories, true notarised documents, are choked full with details on the way of life of XVIIIth century apothecares. The most interesting of them describe exactly for us the content of apothecaries: drugs, remedies, pots, etc. starting from the examples of two representative regions of metropolitan France and its colonies, linked by a history of immigration that is Low-Normandy, which sent a number of its people to North America, and Canada. We will examine apothecaries' material possessions and the tolls of their daily trade. One primordial question emerges: the influence of Amerindian medicine on French and French-Canada XVIIIth century pharmacy.