A scheme for the environmental and hygienic assessment of a functioning solid domestic waste (SDW) burial ground was experimentally tested, by taking into account regional features. The study involved the assessment of climatic, geological, and hydrogeological features of the region, the sanitary-and-hygienic assessment of the activity of a SDW burial ground, and the hygienic assessment of ambient air, soil, and water in the SDW burial ground functioning area. The developed scheme may be used to modify a manufacturing inspection program.