The article presents the methodology to be applied to any class of disease, the socially dangerous illnesses included. The need in the organization of intersectoral coordination body to manage disease prevention activities and certification of disease prevention technologies is discussed. The necessity to implement the medical science achievements in the common public health practice is emphasized. The possibility to organize the intermediate structures contributing to surmount the gap between theory and practice is discussed. To actualize the principles of prevention and population dispanserization corresponding normative legal base, financing, political support of ruling political parties, sweeping implementation of historical experience and consideration of international experience in the field of prevention practice are needed.